Dr Belinda Phipson is a laboratory head within the Bioinformatics Division at The Walter and Eliza Hall Institute of Medical Research, commencing January 2022. The focus of her research is to develop novel bioinformatics methods to leverage large genomic datasets in order to understand the mechanisms of healthy development and disease. Belinda holds a PhD in Statistical Bioinformatics from the University of Melbourne and is supported by an NHMRC Emerging Leader Investigator Grant.
All papers under Belinda’s ORCID:
2023
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7
Cell Reports
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01 Jan 2023
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doi:10.1016/j.celrep.2022.111980
2022
Heterotopic reduction of forelimb progenitors underpins development of the vestigial emu wing; implications for vertebrate limb evolution
Cold Spring Harbor Laboratory
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25 Nov 2022
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doi:10.1101/2022.11.23.516993
propeller: testing for differences in cell type proportions in single cell data
Bioinformatics
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14 Oct 2022
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doi:10.1093/bioinformatics/btac582
Defining the Fetal Gene Program at Single-Cell Resolution in Pediatric Dilated Cardiomyopathy
Circulation
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04 Oct 2022
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doi:10.1161/CIRCULATIONAHA.121.057763
2021
Gene set enrichment analysis for genome-wide DNA methylation data
Genome Biology
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08 Jun 2021
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doi:10.1186/s13059-021-02388-x
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Circulation
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20 Apr 2021
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doi:10.1161/circulationaha.120.051921
2019
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.
Development (Cambridge, England)
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12 Jun 2019
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pmid:31118232
2018
Evaluation of variability in human kidney organoids.
Nature methods
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20 Dec 2018
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pmid:30573816
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.
Nature communications
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04 Dec 2018
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pmid:30514835
Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period
PLOS ONE
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19 Sep 2018
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doi:10.1371/journal.pone.0204038
STRetch: detecting and discovering pathogenic short tandem repeat expansions
Genome Biology
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21 Aug 2018
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doi:10.1186/s13059-018-1505-2
Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database
PLOS Computational Biology
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25 Jun 2018
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doi:10.1371/journal.pcbi.1006245
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms
The American Journal of Human Genetics
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01 May 2018
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doi:10.1016/j.ajhg.2018.03.014
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number
Kidney International
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01 Mar 2018
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doi:10.1016/j.kint.2017.09.015
2017
Splatter: simulation of single-cell RNA sequencing data
Genome Biology
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12 Sep 2017
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doi:10.1186/s13059-017-1305-0
Gene length and detection bias in single cell RNA sequencing protocols
F1000Research
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28 Apr 2017
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doi:10.12688/f1000research.11290.1
A cross-package Bioconductor workflow for analysing methylation array data
F1000Research
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05 Apr 2017
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doi:10.12688/f1000research.8839.3
2016
Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros
Nature Biotechnology
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17 Oct 2016
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doi:10.1038/nbt.3702
Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia
Leukemia
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14 Oct 2016
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doi:10.1038/leu.2016.279
Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
The Annals of Applied Statistics
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01 Jun 2016
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doi:10.1214/16-aoas920
2015
missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform
Bioinformatics
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30 Sep 2015
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doi:10.1093/bioinformatics/btv560
Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
PLOS Genetics
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14 May 2015
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doi:10.1371/journal.pgen.1005211
MOZ and BMI1 play opposing roles during
Hox
gene activation in ES cells and in body segment identity specification in vivo
Proceedings of the National Academy of Sciences
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14 Apr 2015
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doi:10.1073/pnas.1422872112
MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway
Oncogene
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16 Mar 2015
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doi:10.1038/onc.2015.33
limma powers differential expression analyses for RNA-sequencing and microarray studies
Nucleic Acids Research
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20 Jan 2015
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doi:10.1093/nar/gkv007
2014
DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging
Genome Biology
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01 Sep 2014
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doi:10.1186/s13059-014-0465-4
2013
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma
Blood
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10 Oct 2013
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doi:10.1182/blood-2013-02-484055
2012
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Blood
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14 Jun 2012
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doi:10.1182/blood-2011-12-400929
Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene
Journal of Biological Chemistry
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01 Jun 2012
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doi:10.1074/jbc.M111.327601
Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs
Cell Death & Disease
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10 May 2012
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doi:10.1038/cddis.2012.42
2011
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
Blood
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01 Sep 2011
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doi:10.1182/blood-2010-06-286393
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
The Journal of Immunology
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15 Jul 2011
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doi:10.4049/jimmunol.1101176
2010
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
Blood
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09 Dec 2010
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doi:10.1182/blood-2010-04-280818
A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility
Genome Research
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04 Nov 2010
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doi:10.1101/gr.101881.109
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Blood
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05 Aug 2010
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doi:10.1182/blood-2009-12-260760
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
Diabetes
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31 Mar 2010
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doi:10.2337/db09-0287
Permutation P-values Should Never Be Zero: Calculating Exact P-values When Permutations Are Randomly Drawn
Statistical Applications in Genetics and Molecular Biology
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31 Jan 2010
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doi:10.2202/1544-6115.1585
2009
Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles
Proceedings of the National Academy of Sciences
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10 Nov 2009
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doi:10.1073/pnas.0910354106
Molecular dissection of the pea shoot apical meristem*
Journal of Experimental Botany
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25 Aug 2009
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doi:10.1093/jxb/erp254