Phipson Lab

Research

The Phipson laboratory develops novel bioinformatics methods and undertakes collaborative projects with scientists both within the Institute and internationally. Our work combines statistical innovation with biological insight to reveal patterns in complex genomic data, with a strong emphasis on understanding normal development and disease. Much of our research is motivated by advances in single-cell and spatial technologies, where sophisticated modeling is essential for extracting meaningful biological conclusions.

Our research spans multiple areas of computational biology and bioinformatics:

Single-Cell Genomics: We focus on developing statistical methods tailored for single-cell sequencing data. Our work emphasizes rigorous approaches for analyzing cell type composition across conditions, assessing variability between biological replicates, and ensuring that experimental designs are statistically sound.

Spatial Transcriptomics: We create methods to integrate gene expression data with spatial context, enabling the study of cellular organization within tissues. This allows us to uncover spatially resolved patterns that provide new insights into tissue development, disease progression, and cellular interactions.

Cytometry Analysis: We design approaches for large-scale cytometry datasets, enabling efficient summarization of high-dimensional measurements across millions of cells. These methods allow researchers to capture cellular heterogeneity while reducing computational burden.

Collaborative Research: We work closely with experimental biologists to apply our methods to real-world problems in developmental biology, cancer, and immunology. These collaborations ensure our methodological innovations directly contribute to biological discovery and clinical impact.

All our novel bioinformatics methods are implemented as publicly available open-source software through the Bioconductor project, ensuring reproducibility and accessibility for the research community.

Highlighted

<i>propeller:</i>testing for differences in cell type proportions in single cell data
propeller:testing for differences in cell type proportions in single cell data
Belinda Phipson, Choon Boon Sim, Enzo R Porrello, Alex W Hewitt, Joseph Powell, Alicia Oshlack
Bioinformatics  ·  14 Oct 2022  ·  doi:10.1093/bioinformatics/btac582
propeller: testing for differences in cell type proportions in single cell data. Novel statistical methods for analyzing single-cell RNA-seq data with biological replication, addressing the challenges of experimental design in single-cell genomics.
Publication
Website
software single-cell
SuperCellCyto: enabling efficient analysis of large scale cytometry datasets
SuperCellCyto: enabling efficient analysis of large scale cytometry datasets
Givanna H. Putri, George Howitt, Felix Marsh-Wakefield, Thomas M. Ashhurst, Belinda Phipson
Genome Biology  ·  08 Apr 2024  ·  doi:10.1186/s13059-024-03229-3
SuperCellCyto: enabling efficient analysis of large scale cytometry datasets. An extension of the SuperCell R package tailored for cytometry data analysis, authored by Putri et al. (2024) in Genome Biology.
Publication
Website
cytometry software

All

2024

Library size confounds biology in spatial transcriptomics data
Library size confounds biology in spatial transcriptomics data
Dharmesh D. Bhuva, Chin Wee Tan, Agus Salim, Claire Marceaux, Marie A. Pickering, …, Wayne D. Tilley, Theresa E. Hickey, Marie-Liesse Asselin-Labat, Belinda Phipson, Melissa J. Davis
Genome Biology  ·  18 Apr 2024  ·  doi:10.1186/s13059-024-03241-7
SuperCellCyto: enabling efficient analysis of large scale cytometry datasets
SuperCellCyto: enabling efficient analysis of large scale cytometry datasets
Givanna H. Putri, George Howitt, Felix Marsh-Wakefield, Thomas M. Ashhurst, Belinda Phipson
Genome Biology  ·  08 Apr 2024  ·  doi:10.1186/s13059-024-03229-3
SuperCellCyto: enabling efficient analysis of large scale cytometry datasets. An extension of the SuperCell R package tailored for cytometry data analysis, authored by Putri et al. (2024) in Genome Biology.
Publication
Website
cytometry software
GLMsim: a GLM-based single cell RNA-seq simulator incorporating batch and biological effects
GLMsim: a GLM-based single cell RNA-seq simulator incorporating batch and biological effects
Jianan Wang, Lizhong Chen, Rachel Thijssen, Belinda Phipson, Terence P. Speed
Cold Spring Harbor Laboratory  ·  23 Mar 2024  ·  doi:10.1101/2024.03.20.586030
Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptors
Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptors
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, …, Renea A Taylor, Mitchell G Lawrence, Gail Risbridger, Roxanne Toivanen, David L Goode
Cold Spring Harbor Laboratory  ·  19 Mar 2024  ·  doi:10.1101/2024.03.17.585125
In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection
In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection
Chin Wee Tan, Jinjin Chen, Ning Liu, Dharmesh D. Bhuva, Tony Blick, …, John Fraser, Gabrielle T. Belz, Fernando Souza-Fonseca-Guimaraes, Arutha Kulasinghe, Melissa J. Davis
eBioMedicine  ·  01 Mar 2024  ·  doi:10.1016/j.ebiom.2024.105016

2023

Extraction and quantification of lineage-tracing barcodes with NextClone and CloneDetective
Extraction and quantification of lineage-tracing barcodes with NextClone and CloneDetective
Givanna H. Putri, Nichelle Pires, Nadia M. Davidson, Catherine Blyth, Aziz M. Al’Khafaji, Shom Goel, Belinda Phipson
Cold Spring Harbor Laboratory  ·  20 Nov 2023  ·  doi:10.1101/2023.11.19.567755
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in <i>RUNX1</i>, <i>GATA2</i>, and <i>DDX41</i>
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41
Claire C. Homan, Michael W. Drazer, Kai Yu, David M. Lawrence, Jinghua Feng, …, Christopher N. Hahn, Hamish S. Scott, Paul Liu, Lucy A. Godley, Anna L. Brown
Blood Advances  ·  12 Oct 2023  ·  doi:10.1182/bloodadvances.2023010045
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7
Andrew J. Kueh, Maria I. Bergamasco, Anna Quaglieri, Belinda Phipson, Connie S.N. Li-Wai-Suen, …, Michael P. Snyder, Gordon K. Smyth, Terence P. Speed, Tim Thomas, Anne K. Voss
Cell Reports  ·  01 Jan 2023  ·  doi:10.1016/j.celrep.2022.111980

2022

Heterotopic reduction of forelimb progenitors underpins development of the vestigial emu wing; implications for vertebrate limb evolution
Heterotopic reduction of forelimb progenitors underpins development of the vestigial emu wing; implications for vertebrate limb evolution
Axel H Newton, Sarah M Williams, Belinda Phipson, Andrew J Pask, Andrew T Major, Craig A Smith
Cold Spring Harbor Laboratory  ·  25 Nov 2022  ·  doi:10.1101/2022.11.23.516993
<i>propeller:</i>testing for differences in cell type proportions in single cell data
propeller:testing for differences in cell type proportions in single cell data
Belinda Phipson, Choon Boon Sim, Enzo R Porrello, Alex W Hewitt, Joseph Powell, Alicia Oshlack
Bioinformatics  ·  14 Oct 2022  ·  doi:10.1093/bioinformatics/btac582
propeller: testing for differences in cell type proportions in single cell data. Novel statistical methods for analyzing single-cell RNA-seq data with biological replication, addressing the challenges of experimental design in single-cell genomics.
Publication
Website
software single-cell
Defining the Fetal Gene Program at Single-Cell Resolution in Pediatric Dilated Cardiomyopathy
Defining the Fetal Gene Program at Single-Cell Resolution in Pediatric Dilated Cardiomyopathy
Neda R. Mehdiabadi, Choon Boon Sim, Belinda Phipson, Ravi K.R. Kalathur, Yuliangzi Sun, …, Robert G. Weintraub, Igor E. Konstantinov, Nathan J. Palpant, David A. Elliott, Enzo R. Porrello
Circulation  ·  04 Oct 2022  ·  doi:10.1161/CIRCULATIONAHA.121.057763

2021

Gene set enrichment analysis for genome-wide DNA methylation data
Gene set enrichment analysis for genome-wide DNA methylation data
Jovana Maksimovic, Alicia Oshlack, Belinda Phipson
Genome Biology  ·  08 Jun 2021  ·  doi:10.1186/s13059-021-02388-x
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J. Mills, …, David A. Elliott, Assam El-Osta, Alicia Oshlack, James E. Hudson, Enzo R. Porrello
Circulation  ·  20 Apr 2021  ·  doi:10.1161/circulationaha.120.051921

2019

Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673)
Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673)
Alexander N. Combes, Belinda Phipson, Kynan T. Lawlor, Aude Dorison, Ralph Patrick, Luke Zappia, Richard P. Harvey, Alicia Oshlack, Melissa H. Little
Development  ·  01 Jul 2019  ·  doi:10.1242/dev.182162
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.
Alexander N Combes, Belinda Phipson, Kynan T Lawlor, Aude Dorison, Ralph Patrick, Luke Zappia, Richard P Harvey, Alicia Oshlack, Melissa H Little
Development (Cambridge, England)  ·  12 Jun 2019  ·  pmid:31118232

2018

Evaluation of variability in human kidney organoids.
Evaluation of variability in human kidney organoids.
Belinda Phipson, Pei X Er, Alexander N Combes, Thomas A Forbes, Sara E Howden, …, Jane Sun, Ernst Wolvetang, Minoru Takasato, Alicia Oshlack, Melissa H Little
Nature methods  ·  20 Dec 2018  ·  pmid:30573816
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.
Lorna J Hale, Sara E Howden, Belinda Phipson, Andrew Lonsdale, Pei X Er, …, Shahnaz Khan, Alicia Oshlack, Catherine Quinlan, Rachel Lennon, Melissa H Little
Nature communications  ·  04 Dec 2018  ·  pmid:30514835
Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period
Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period
Ramona H. Krauss, Belinda Phipson, Alicia Oshlack, Nikita Prasad-Gupta, Michael M. Cheung, Joseph J. Smolich, Salvatore Pepe
PLOS ONE  ·  19 Sep 2018  ·  doi:10.1371/journal.pone.0204038
STRetch: detecting and discovering pathogenic short tandem repeat expansions
STRetch: detecting and discovering pathogenic short tandem repeat expansions
Harriet Dashnow, Monkol Lek, Belinda Phipson, Andreas Halman, Simon Sadedin, …, Phillipa Lamont, Joshua S. Clayton, Nigel G. Laing, Daniel G. MacArthur, Alicia Oshlack
Genome Biology  ·  21 Aug 2018  ·  doi:10.1186/s13059-018-1505-2
Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database
Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database
Luke Zappia, Belinda Phipson, Alicia Oshlack
PLOS Computational Biology  ·  25 Jun 2018  ·  doi:10.1371/journal.pcbi.1006245
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms
Thomas A. Forbes, Sara E. Howden, Kynan Lawlor, Belinda Phipson, Jovana Maksimovic, …, Alicia Oshlack, Chirag Patel, Andrew Mallett, Cas Simons, Melissa H. Little
The American Journal of Human Genetics  ·  01 May 2018  ·  doi:10.1016/j.ajhg.2018.03.014
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number
Alexander N. Combes, Sean Wilson, Belinda Phipson, Brandon B. Binnie, Adler Ju, …, Ian M. Smyth, Karen M. Moritz, Raphael Kopan, Alicia Oshlack, Melissa H. Little
Kidney International  ·  01 Mar 2018  ·  doi:10.1016/j.kint.2017.09.015

2017

Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells
Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells
Belinda Phipson, Pei X Er, Lorna Hale, David Yen, Kynan Lawlor, Minoru Takasato, Jane Sun, Ernst Wolvetang, Alicia Oshlack, Melissa H Little
Cold Spring Harbor Laboratory  ·  22 Dec 2017  ·  doi:10.1101/238428
High throughput single cell RNA-seq of developing mouse kidney and human kidney organoids reveals a roadmap for recreating the kidney
High throughput single cell RNA-seq of developing mouse kidney and human kidney organoids reveals a roadmap for recreating the kidney
Alexander N. Combes, Belinda Phipson, Luke Zappia, Kynan T. Lawlor, Pei Xuan Er, Alicia Oshlack, Melissa H. Little
Cold Spring Harbor Laboratory  ·  16 Dec 2017  ·  doi:10.1101/235499
Splatter: simulation of single-cell RNA sequencing data
Splatter: simulation of single-cell RNA sequencing data
Luke Zappia, Belinda Phipson, Alicia Oshlack
Genome Biology  ·  12 Sep 2017  ·  doi:10.1186/s13059-017-1305-0
Gene length and detection bias in single cell RNA sequencing protocols
Gene length and detection bias in single cell RNA sequencing protocols
Belinda Phipson, Luke Zappia, Alicia Oshlack
F1000Research  ·  28 Apr 2017  ·  doi:10.12688/f1000research.11290.1
A cross-package Bioconductor workflow for analysing methylation array data
A cross-package Bioconductor workflow for analysing methylation array data
Jovana Maksimovic, Belinda Phipson, Alicia Oshlack
F1000Research  ·  05 Apr 2017  ·  doi:10.12688/f1000research.8839.3

2016

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros
Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros
Elizabeth S Ng, Lisa Azzola, Freya F Bruveris, Vincenzo Calvanese, Belinda Phipson, …, Katja Schenke-Layland, Alicia Oshlack, Hanna K A Mikkola, Edouard G Stanley, Andrew G Elefanty
Nature Biotechnology  ·  17 Oct 2016  ·  doi:10.1038/nbt.3702
Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia
Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia
N Narayan, L Morenos, B Phipson, S N Willis, G Brumatti, …, D Catchpoole, R Saffery, A Oshlack, G J Goodall, P G Ekert
Leukemia  ·  14 Oct 2016  ·  doi:10.1038/leu.2016.279
Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
Belinda Phipson, Stanley Lee, Ian J. Majewski, Warren S. Alexander, Gordon K. Smyth
The Annals of Applied Statistics  ·  01 Jun 2016  ·  doi:10.1214/16-aoas920

2015

missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform
missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform
Belinda Phipson, Jovana Maksimovic, Alicia Oshlack
Bioinformatics  ·  30 Sep 2015  ·  doi:10.1093/bioinformatics/btv560
Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
Ashley P. Ng, Yifang Hu, Donald Metcalf, Craig D. Hyland, Helen Ierino, …, Hiu Kiu, Ladina Di Rago, Douglas J. Hilton, Gordon K. Smyth, Warren S. Alexander
PLOS Genetics  ·  14 May 2015  ·  doi:10.1371/journal.pgen.1005211
MOZ and BMI1 play opposing roles during <i>Hox</i> gene activation in ES cells and in body segment identity specification in vivo
MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo
Bilal N. Sheikh, Natalie L. Downer, Belinda Phipson, Hannah K. Vanyai, Andrew J. Kueh, Davis J. McCarthy, Gordon K. Smyth, Tim Thomas, Anne K. Voss
Proceedings of the National Academy of Sciences  ·  14 Apr 2015  ·  doi:10.1073/pnas.1422872112
MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway
MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway
B N Sheikh, B Phipson, F El-Saafin, H K Vanyai, N L Downer, …, A J Kueh, R E May, G K Smyth, A K Voss, T Thomas
Oncogene  ·  16 Mar 2015  ·  doi:10.1038/onc.2015.33
limma powers differential expression analyses for RNA-sequencing and microarray studies
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W. Law, Wei Shi, Gordon K. Smyth
Nucleic Acids Research  ·  20 Jan 2015  ·  doi:10.1093/nar/gkv007

2014

DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging
DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging
Belinda Phipson, Alicia Oshlack
Genome Biology  ·  23 Sep 2014  ·  doi:10.1186/s13059-014-0465-4

2013

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma
Stanley C. W. Lee, Belinda Phipson, Craig D. Hyland, Huei San Leong, Rhys S. Allan, …, Stephen L. Nutt, Marnie E. Blewitt, Gordon K. Smyth, Warren S. Alexander, Ian J. Majewski
Blood  ·  10 Oct 2013  ·  doi:10.1182/blood-2013-02-484055

2012

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Delphine Mérino, Seong L. Khaw, Stefan P. Glaser, Daniel J. Anderson, Lisa D. Belmont, …, Suzanne Cory, Andrew W. Roberts, Mary J. C. Ludlam, David C. S. Huang, Philippe Bouillet
Blood  ·  14 Jun 2012  ·  doi:10.1182/blood-2011-12-400929
Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene
Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene
Dillon W. Leong, Jasper C. Komen, Chelsee A. Hewitt, Estelle Arnaud, Matthew McKenzie, …, Albert Sickmann, Michael T. Ryan, Gordon K. Smyth, David R. Thorburn, Hamish S. Scott
Journal of Biological Chemistry  ·  01 Jun 2012  ·  doi:10.1074/jbc.M111.327601
Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs
Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs
L Happo, B Phipson, G K Smyth, A Strasser, C L Scott
Cell Death & Disease  ·  10 May 2012  ·  doi:10.1038/cddis.2012.42

2011

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
François-Xavier Hubert, Sarah A. Kinkel, Gayle M. Davey, Belinda Phipson, Scott N. Mueller, …, Li Wu, Christopher C. Goodnow, Francis R. Carbone, Hamish S. Scott, William R. Heath
Blood  ·  01 Sep 2011  ·  doi:10.1182/blood-2010-06-286393
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Mireille H Lahoud, Fatma Ahmet, Susie Kitsoulis, Soo San Wan, David Vremec, …, Scott N Mueller, Gayle M Davey, William R Heath, Ken Shortman, Irina Caminschi
The Journal of Immunology  ·  01 Jul 2011  ·  doi:10.4049/jimmunol.1101176

2010

Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
Lina Happo, Mark S. Cragg, Belinda Phipson, Jon M. Haga, Elisa S. Jansen, …, Cassandra J. Vandenberg, Gordon K. Smyth, Andreas Strasser, Suzanne Cory, Clare L. Scott
Blood  ·  09 Dec 2010  ·  doi:10.1182/blood-2010-04-280818
A recombination hotspot leads to sequence variability within a novel gene (<i>AK005651</i>) and contributes to type 1 diabetes susceptibility
A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility
Iris K.L. Tan, Leanne Mackin, Nancy Wang, Anthony T. Papenfuss, Colleen M. Elso, …, Melanie Bahlo, Terence P. Speed, Gordon K. Smyth, Grant Morahan, Thomas C. Brodnicki
Genome Research  ·  04 Nov 2010  ·  doi:10.1101/gr.101881.109
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Ian J. Majewski, Matthew E. Ritchie, Belinda Phipson, Jason Corbin, Miha Pakusch, …, Yifang Hu, Gordon K. Smyth, Warren S. Alexander, Douglas J. Hilton, Marnie E. Blewitt
Blood  ·  05 Aug 2010  ·  doi:10.1182/blood-2009-12-260760
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
John M. Wentworth, Gaetano Naselli, Wendy A. Brown, Lisa Doyle, Belinda Phipson, Gordon K. Smyth, Martin Wabitsch, Paul E. O’Brien, Leonard C. Harrison
Diabetes  ·  31 Mar 2010  ·  doi:10.2337/db09-0287
Permutation P-values Should Never Be Zero: Calculating Exact P-values When Permutations Are Randomly Drawn
Permutation P-values Should Never Be Zero: Calculating Exact P-values When Permutations Are Randomly Drawn
Belinda Phipson, Gordon K Smyth
Statistical Applications in Genetics and Molecular Biology  ·  31 Jan 2010  ·  doi:10.2202/1544-6115.1585

2009

Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles
Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles
Donald Metcalf, Ashley P. Ng, Stephen J. L. Loughran, Belinda Phipson, Gordon K. Smyth, Ladina Di Rago, Sandra Mifsud
Proceedings of the National Academy of Sciences  ·  10 Nov 2009  ·  doi:10.1073/pnas.0910354106
Molecular dissection of the pea shoot apical meristem*
Molecular dissection of the pea shoot apical meristem*
Dacheng Liang, Chui E. Wong, Mohan B. Singh, Christine A. Beveridge, Belinda Phipson, Gordon K. Smyth, Prem L. Bhalla
Journal of Experimental Botany  ·  25 Aug 2009  ·  doi:10.1093/jxb/erp254